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Hum. Mol. Genet. (2013) 22 (13): 2642-2651.
Environmental factors including ionizing radiation and chemical agents have been known to be able to induce DNA rearrangements and cause genomic structural variations (SVs); however, the roles of intrinsic characteristics of the human genome, such as regional...
In June
In June REN Luyao will become a graduate student of School of Life Sciences,Fudan University. Wish her an academic success and a smooth life of scientific research. Our graduate student ZHANG Xue, who now is a clinical research specialistat Medtronic Inc. Wish her a happy work. Dr.CHEN Lu will go to the...Welcome
Welcome Professor Yanhua Wu and her team. We all believe the new collaborations will be fruitfill.TBX6 Null Variants and a Common Hypomorphic Allele in Congenital Scoliosis
N Engl J Med. 2015 Jan 22;372(4):341-50. Background: Congenital scoliosis is a common type of vertebral malformation. Genetic susceptibility has been implicated in congenital scoliosis. Methods: We evaluated 161 Han Chinese persons with sporadic congenital scoliosis, 166 Han Chinese controls, and 2...Journal Club-Genome editing with RNA guided Cas9 nuclease in Zebrafish embryos
This is an original article published in early 2013 in Cell Research magazine. It mainly includes four parts of experiments: Cas9/gRNA ribonucleoprotein complex executes site-specific DNA cleavage in mammalian cells; Cas9/gRNA induces indels in the etsrp locus in zebrafish; Cas9/gRNA induces indels in...Increased genome instability in human DNA segments with self-chains: homology-induced structural variations via replicative mechanisms